Mastocytosis
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Mastocytosis
Mastocytosis - What it is
Mastocytosis refers to a group of diseases caused by accumulation of mast cells (a type of white blood cell) in the skin and, rarely, other organs of the body. It is most commonly seen in infants and children.
Mastocytosis - Symptoms
Mastocytomas are the most common presentation of cutaneous mastocytosis. They present as yellowish-orange to pigmented raised lesions. Although most patients present with one lesion, some patients may present with several lesions. The surface may be irregular, described as having a "peau-de-orange" appearance. Occasionally, blistering can occur at the site of the lesion.
Urticaria pigmentosa is the next most common type of cutaneous mastocytosis in children. Patients present with a few to many brownish-grey flat or slightly raised lesions.
The lesions of mastocytosis may become red and develop a wheal or blister if rubbed vigorously (Darier's sign).
Some patients may develop systemic symptoms from break-down of mast cells with release of achemical called histamine. These include nausea, abdominal pain, diarrhoea, low blood pressure and breathing difficulties.
Mastocytosis - How to prevent?
Mastocytosis - Causes and Risk Factors
Potential Triggers of Mast Cell Degranulation and Histamine Release:
Physical: Exercise, hot baths, hot beverages, extreme temperatures (heat/ cold), sunlight, emotional stress, friction
Medications (always inform your doctor beforehand that you/ your child has mastocytosis):
Systemic: Aspirin, NSAIDs, morphine, opiates, codeine, dextromethorphan, amphotericin B, quinine, vancomycin, thiamine
Topical: Polymyxin B
Some medications used in general anaesthesia
Local anaesthetics: Tetracaine, procaine, methylparaben preservative
Radiologic contrast media
Venoms: Snakebites, bee stings, jellyfish stings
Foods: Monosodium glutamate (MSG), shellfish, chocolate, tomatoes, citrus fruits, alcohol, artificial food dyes and flavourings
Mastocytosis - Diagnosis
The diagnosis of mastocytosis is usually made clinically. However, in unusual cases, your doctor may recommend a skin punch biopsy to confirm the diagnosis.
Your doctor may order a blood test (serum tryptase) to evaluate for systemic disease.
Mastocytosis - Treatments
Most lesions will resolve after a few years. However, a small number of patients may have lesions that last till adulthood. Residual pigmentation may remain after regression of childhood disease.
The treatment of mastocytosis is mostly symptomatic, as there is no specific therapy or cure.
Some mastocytomas may improve or disappear with application of potent topical steroids.
Antihistamines may be given in patients with more symptomatic disease. These include but are not limited to cetirizine, loratadine, and hydroxyzine.
Other treatment options for patients with more severe symptoms include H2-blockers, cromolyn sodium, ketotifen, montelukast and phototherapy.
Your doctor may prescribe an epinephrine pen kit (EpiPen) if your child is at high risk of developing low blood pressure (hypotension) from degranulation of mast cells. It should be kept with your child at all times for emergency use.
The information above is also available for download in pdf format.
Mastocytosis - Preparing for surgery
Mastocytosis - Post-surgery care
Mastocytosis - Other Information
Overview
Article contributed by
Dermatology Service
,
KK Women's and Children's Hospital
;
Dermatology Service
,
KK Women's and Children's Hospital
The information provided is not intended as medical advice.
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