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Lenvatinib

Drug Class: Commonly Known As: Category:
Multi-Kinase Inhibitor Lenvima® Cancer-related

Lenvatinib - Side Effects, Precautions, and Contraindications

What side effects can Lenvatinib cause?

  • Increased blood pressure
    • Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.
  • Feeling tired and lack of energy
    • Do not drive or operate machinery when you feel tired
  • Diarrhea
    • Drink plenty of clear fluids to replace those lost (two litres everyday)
  • Decreased appetite, nausea or vomiting
    • Take small, frequent meals throughout the day
  • Mouth sores or ulcers
    • Rinse your mouth after every meal using an alcohol-free mouthwash or salt water
    • Brush your teeth with a soft toothbrush
  • Voice hoarseness
  • Stomach discomfort
  • Weight loss
  • Joint or muscle ache, headache
    • You may take paracetamol when necessary to help with this
  • Palms of the hands or soles of the feet may become numb, sore, red or dr
    • Moisturize these areas daily
    • Avoid wearing tight-fitting shoes

 If you experience any of the following symptoms, you should stop your medication and see your healthcare professional immediately.

  • Abnormal heartbeat, chest pain or shortness of breath
  • Very bad swelling of hands, feet or lower legs
  • Dark urine or light coloured stools
  • Yellowing of your eyes or skin
  • Very bad diarrhea, nausea, vomiting or stomach pain
  • Pain while urinating
  • Abnormal muscle cramps or numbness
  • Unusual weakness, tiredness or lightheadedness
  • Unusual bleeding, bruising, black sticky stools or blood in urine
  • Symptoms of a drug allergy including one or more of the following:
    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

Before taking Lenvatinib, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You or your partners becomes pregnant or is planning for pregnancy
    • You should use effective birth control during and for at least one month after stopping treatment.
  • You are breastfeeding
    • Do not breastfeed during and for at least two weeks after stopping treatment
  • You are taking any other medications, including supplements, traditional medications, and herbal remedies
  • You have any other medical conditions (e.g. heart problems, high blood pressure)
  • You have any recent or upcoming surgery

What food or medicine must I avoid when I take Lenvatinib?

​Avoid medications that are known to interfere with heart rhythms.

Lenvatinib - Additional Information

  • Updated on Monday, August 31, 2020
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

    ​​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

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