Wisdom tooth Other area Osimertinib - Side Effects, Precautions and Contraindications
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Drug Class: Commonly Known As: Category:
Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Tagrisso Cancer-related

Osimertinib - Side Effects, Precautions, and Contraindications

What side effects can Osimertinib cause?

Common side effects include:

  • Decreased appetite
    • Take small, frequent meals throughout the day.
  • Diarrhoea
    • Drink plenty of clear fluids to replace those lost (2 litres everyday).
    • Avoid oily or spicy food and milk or dairy products.
  • Skin rash (may be acne-like), dry skin, itch
    • Moisturize your skin daily.
    • Avoid too much exposure to the sun as it may make the rash worse. Use sunscreen and covered clothing if you need to be under the sun for a long period of time.
  • Nail changes – ridges (uneven surface), discolouration or redness and tenderness around the nail folds
    • Keep your nails trimmed, clean and dry.
    • Avoid contact with harsh chemicals e.g. detergent or dish-washing liquids. Wear gloves when you are doing household chores.
  • Mouth sores
    • Rinse your mouth after meals using alcohol-free mouthwash or salt water.
    • Brush your teeth with a soft toothbrush.
  • Feeling tired or lack of energy
    • Do not drive or operate machinery when you feel tired.

Rare but serious side effects include:

  • Very bad diarrhoea (e.g. more than 4 times a day) that does not improve even after taking medications used to stop diarrhoea
  • Sudden onset of cough, chest pain or shortness of breath, with fever
  • Severe eye discomfort, sensitivity to light, blurred eyesight
  • Fast or abnormal heartbeat, chest pain, swelling of the hands and feet, or sudden weight gain
  • Unusual bleeding, bruising or black sticky stools
  • Fever of 38° C and above, especially with chills, pain or difficulty in passing urine

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Osimertinib , what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication
  • You or your partner becomes pregnant or is planning for pregnancy. You should use effective birth control during and for at least
    • 4 months after stopping Osimertinib (for men)
    • 6 weeks after stopping Osimertinib (for women)
  • You are breastfeeding
    • Do not breastfeed during treatment
  • You have any other medical conditions such as heart problems or eye problems

What food or medicine must I avoid when I take Osimertinib ?

​Avoid taking grapefruit when you are taking this medication as grapefruit may interact with your medication and increase the risk of side-effects.

Inform your healthcare professional if you are taking or intend to take any other medication, supplements, traditional medications or herbal remedies. Some of these may affect how Osimertinib works.

Osimertinib - Additional Information

​You may refer to the following website if you need more information: https://www.macmillan.org.uk/

  • Updated on 9/30/2019 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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