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Prednisolone (Tablet)

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Prednisolone (Tablet) - Side Effects, Precautions, and Contraindications

What side effects can Prednisolone (Tablet) cause?

  • ​Increased risk of unusual infection
  • Slow wound healing
  • Reactivation of old viral disease such as herpes
  • Poorer diabetic and blood pressure control
  • Salt level disturbance in the blood
  • Gastritis / gastric ulcers
  • Increased appetite and weight gain
  • Water retention leading to swelling of legs and body
  • Depression, euphoria, insomnia, mood swings, personality changes, restlessness
  • Irregular menstrual periods​
If high dose steroids are required over a prolonged period of time, you may develop:
  • Cushing's syndrome
  • Cataracts and glaucoma
  • Reduced immunity to unusual infections
  • Osteoporosis
  • Diabetes mellitus and high blood pressure
  • Thinning of skin / easy bruising
  • Increased hair growth / excessive acne
  • Growth suppression in children

Before taking Prednisolone (Tablet), what precautions must I follow?

​Before taking Prednisolone, tell your doctor if you

  • Are allergic to any drug
  • Are taking any other medications or over-the-counter medications
  • Have liver, kidney or heart disease
  • Have history of gastritis, gastric ulcers, or other intestinal problems
  • Have diabetes mellitus, high blood pressure, thyroid disease or myasthenia gravis
  • Have Hepatitis B or C (including carrier state)
  • Have any type of infection such as tuberculosis (TB) or fungus
  • Have a history of herpes virus eye infection
  • Have a history of osteoporosis or unusual fractures
  • Have depression or any psychiatric problems
  • Are pregnant or breast-feeding, or planning to get pregnant
Other precautions:
  • In order to maximize your safety and the effectiveness of treatment, you must adhere to your specified appointments for close monitoring and treatment adjustment. Regular monitoring of blood pressure, blood sugar and salt levels are important
  • Do NOT adjust or stop your treatment on your own without your doctor's supervision as this may worsen your condition or cause harmful side effects.
  • If you have diabetes mellitus or high blood pressure, it is highly recommended for you to monitor your control closely if you have your own glucometer or automated blood pressure monitoring devices.
  • Your resistance to infections may be reduced during treatment. You should avoid excessive crowds or reduce your chance of acquiring infections such as chicken pox, measles or tuberculosis (TB) from others. You must consult a doctor if you feel unwell or are exposed to people with chicken pox, measles or tuberculosis (TB).
  • Inform your doctor ​about your treatment before​ any immunisation, vaccination or skin tests. You should not receive live vaccines while on high dose treatment.
  • Avoid alcohol while you are taking Prednisolone to avoid gastric ulcers.
  • If you have taken high dose Prednisolone for a prolonged period of time, you may require supplementary ​steroids during periods of stress (e.g severe injuries, infections, asthma attacks, after a major surgery). Do carry an identification card (eg, Medic-Awas card) which indicate your need to any potential emergency medical personnel.
  • Use of high dose steroids during pregnancy may result in low birth weight of fetal abnormality. Steroids can also be secreted into breast milk. Please discuss with your doctor if you intend to breast-feed.

What food or medicine must I avoid when I take Prednisolone (Tablet)?

  • Updated on
  • Article contributed by Pharmacy Department Singapore National Eye Centre

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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