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Asst Prof Chandramouli Chanchal

Asst Prof Chanchal Chandramouli from National Heart Centre Singapore

Asst Prof Chandramouli Chanchal

BSc (Hons), MBA, MAMS, PhD

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Heart Failure

Academic Appointments

  • Assistant Professor SingHealth Duke-NUS Medicine Academic Clinical Programme

Profile

Asst Prof Chandramouli completed her PhD at The University of Melbourne on examining sex differences in diabetic cardiomyopathy. Subsequently, she joined The National Heart Centre Singapore to pursue clinical research. At NHCS, she has co-authored several landmark publications on her key findings on lean diabetes, lean fat and sex differences in heart failure. She holds a concurrent Assistant Professor position at Duke-NUS Medical School.

She is also a key co-investigator in the multinational Asian Diabetes Outcome Prevention Trial (ADOPT) and serves as the youngest Trial Steering Committee and Advisory Board Member. Specifically, her role in the trial include designing, writing the protocol, applying for grants and funding, evaluating and selecting trial sites across Asia, liaising with country heads, co-investigators, project managers and clinical research organization to execute the trial.

She also serves as a Junior Member of the Board of Directors of Worldwide CardioDiabetes, a non-profit organisation. They educate health care professionals in the developing world about the relationship between diabetes and cardiovascular disease.

Education

  • Doctor of Philosophy (Medicine- Cardiac Physiology) University of Melbourne. Sep ‘12- Feb‘16
  • Masters in Management Science (Distinction Class) University of Hertfordshire. Sep ‘11 - Aug ‘12
  • Masters in Business Administration (Distinction Class) INTI International University. Sep ‘11 - Aug ‘12
  • Honours in Medical Bioscience (1st Class Honours) Monash University. Jul ‘10 - Jun ‘11
  • Bachelor of Science in Biomedical Science (Merit) National University of Singapore . Aug ‘07-May ‘10

Professional Appointments and Committee Memberships

  • 2018-2025  Steering Committee Member, Asian Diabetes Outcome Prevention Trial
  • 2021-2023  Junior Member of Board of Directors, Worldwide CardioDiabetes
  • 2018-2022  Full Member, European Society of Cardiology
  • 2018-2022  Member, Heart Failure Association of European Society of Cardiology
  • 2018-2021  Pro-term member, SingHealth Global Health - Research workgroup

Awards

  • 2020 Biomarkers of Paris Congress Finalist for Young Investigator Award
  • 2019 European Society of Cardiology, Athens 2019 Travel Grant
  • 2018 Early Career Research Award, Heart Failure Seoul 2018, Seoul, Korea
  • 2018 European Society of Cardiology, Vienna 2018 Travel Grant
  • 2015 MV Anderson Award for Excellence in Scientific Pursuits, Graduate Union of Victoria
  • 2013 Best Student Presenter, Australian Physiological Society Conference, Australia
  • 2011 Best Graduate Award, Monash University, Kuala Lumpur
  • 2009 NUS Student Achievement Awards for Community Service, Singapore

Research Interests

  • Heart Failure
  • Clinical Trials
  • Diabetes
  • Cardiometabolic disease
  • Sex differences

Publications

  • Chandramouli C, Chien SC, Lo CI, Lin CF, Sung KT, Huang WH, Lai YH, Yun CH, Su CH, Yeh HI, Hung TC, Hung CL and Lam CSP. Associations of obesity and malnutrition with cardiac remodeling and cardiovascular outcomes in Asian adults: A cohort study. PLoS medicine. 2021;18:e1003661.
  • Chandramouli C, Teng TK, Tay WT, Yap J, MacDonald MR, Tromp J, Yan L, Siswanto B, Reyes EB, Ngarmukos T, Yu CM, Hung CL, Anand I, Richards AM, Ling LH, Regensteiner JG and Lam CSP. Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. European journal of heart failure. 2019;21:297-307.
  • Chandramouli C, Tay WT, Bamadhaj NS, Tromp J, Teng TK, Yap JJL, MacDonald MR, Hung CL, Streng K, Naik A, Wander GS, Sawhney J, Ling LH, Richards AM, Anand I, Voors AA and Lam CSP. Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. PLoS medicine. 2019;16:e1002916.
  • Jin X, Chandramouli C, Allocco B, Gong E, Lam CSP and Yan LL. Women's Participation in Cardiovascular Clinical Trials From 2010 to 2017. Circulation. 2020;141:540-548.
  • Lam CSP, Chandramouli C, Ahooja V and Verma S. SGLT-2 Inhibitors in Heart Failure: Current Management, Unmet Needs, and Therapeutic Prospects. Journal of the American Heart Association. 2019;8:e013389.
  • Teng TK, Tay WT, Richards AM, Chew TSM, Anand I, Ouwerkerk W, Chandramouli C, Huang W, Lawson CA, Kadam UT, Yap J, Lim S, Hung CL, MacDonald MR, Loh SY, Shimizu W, Tromp J and Lam CSP. Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia. Circulation Cardiovascular quality and outcomes. 2021;14:e006962.
  • Yap J, Tay WT, Teng TK, Anand I, Richards AM, Ling LH, MacDonald MR, Chandramouli C, Tromp J, Siswanto BB, Zile M, McMurray J and Lam CSP. Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction. Journal of the American Heart Association. 2019;8:e013114.
  • Tromp J, Lim SL, Tay WT, Teng TK, Chandramouli C, Ouwerkerk W, Wander GS, Sawhney JPS, Yap J, MacDonald MR, Ling LH, Sattar N, McMurray JJV, Richards AM, Anand I and Lam CSP. Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction. Diabetes care. 2019;42:1792-1799.
  • Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K and Voors AA. Sex differences in heart failure. European heart journal. 2019;40:3859-3868c.
  • Chia YMF, Teng TK, Tay WT, Anand I, MacDonald MR, Yap J, Chandramouli C, Richards AM, Tromp J, Ouwerkerk W, Ling LH and Lam CSP. Prescription patterns of anti-diabetic medications and clinical outcomes in Asian patients with heart failure and diabetes mellitus. European journal of heart failure. 2019;21:685-688.
  • Lam CSP and Chandramouli C. Fat, Female, Fatigued: Features of the Obese HFpEF Phenotype. JACC Heart failure. 2018;6:710-713.
  • Curl CL, Danes VR, Bell JR, Raaijmakers AJA, Ip WTK, Chandramouli C, Harding TW, Porrello ER, Erickson JR, Charchar FJ, Kompa AR, Edgley AJ, Crossman DJ, Soeller C, Mellor KM, Kalman JM, Harrap SB and Delbridge LMD. Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model. Journal of the American Heart Association. 2018;7.
  • Chia YMF, Teng TK, Chandramouli C, Yap J, MacDonald M and Lam CSP. Clinical correlates and pharmacological management of Asian patients with concomitant diabetes mellitus and heart failure. Heart failure reviews. 2018;23:461-468.
  • Chandramouli C, Reichelt ME, Curl CL, Varma U, Bienvenu LA, Koutsifeli P, Raaijmakers AJA, De Blasio MJ, Qin CX, Jenkins AJ, Ritchie RH, Mellor KM and Delbridge LMD. Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia. Scientific reports. 2018;8:2346.
  • Ip WTK, Chandramouli C, Smith JA, McLennan PL, Pepe S and Delbridge LMD. A Small Cohort Omega-3 PUFA Supplement Study: Implications of Stratifying According to Lipid Membrane Incorporation in Cardiac Surgical Patients. Heart, lung & circulation. 2017;26:846-855.
  • Kennedy TL, Swiderski K, Murphy KT, Gehrig SM, Curl CL, Chandramouli C, Febbraio MA, Delbridge LM, Koopman R and Lynch GS. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. The American journal of pathology. 2016;186:3246-3260.
  • Chandramouli C, Varma U, Stevens EM, Xiao RP, Stapleton DI, Mellor KM and Delbridge LM. Myocardial glycogen dynamics: new perspectives on disease mechanisms. Clinical and experimental pharmacology & physiology. 2015;42:415-25.
  • Mellor KM, Curl CL, Chandramouli C, Pedrazzini T, Wendt IR and Delbridge LM. Ageing-related cardiomyocyte functional decline is sex and angiotensin II dependent. Age (Dordrecht, Netherlands). 2014;36:9630.
  • Fernando HA, Chandramouli C, Rosli D, Lam YL, Yong ST, Yaw HP, Ton SH, Kadir KA and Sainsbury A. Glycyrrhizic acid can attenuate metabolic deviations caused by a high-sucrose diet without causing water retention in male Sprague-Dawley rats. Nutrients. 2014;6:4856-71.
  • Reichelt ME, Mellor KM, Bell JR, Chandramouli C, Headrick JP and Delbridge LM. Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus. American journal of physiology Heart and circulatory physiology. 2013;305:H779-92.
  • Li Y, Farooq M, Sheng D, Chandramouli C, Lan T, Mahajan NK, Kini RM, Hong Y, Lisowsky T and Ge R. Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis. PloS one. 2012;7:e30835.
  • Annamalai C, Govindaraja C and Chandramouli C. Prevalence, awareness and control of hypertension in estate workers in Malaysia. North American journal of medical sciences. 2011;3:540-3.

 

Media highlights

Findings on underrepresentation of women in cardiovascular clinical trials highlighted at Healio Cardiology and Everyday Health:

ADOPT trial highlighted in The Straits Times Singapore: Asia-wide study on reducing chances of diabetes patients developing heart disease under way, Singapore News & Top Stories - The Straits Times

Discovery of lean-diabetes and lean-fat phenotypes among Asian individuals with heart failure highlighted inThe Straits Times

Research Trials

2020 - 2025  Asian Diabetes Outcome Prevention Trial (Steering Committee Member and Co-investigator)