Dr Tanujaa Suriyanarayanan

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• Research Fellow, National Dental Research Institute Singapore
  
• Instructor, Duke-NUS Graduate Medical School

Dr Tanujaa Suriyanarayanan obtained her doctorate from the Department of Biological Sciences, National University of Singapore. Her doctoral dissertation was focused on elucidating the role of phosphorylation signaling in the virulence and biofilm formation pathways of Pseudomonas aeruginosa. Her current postdoctoral research at NDRIS is directed towards understanding the molecular mechanisms behind the biofilm formation of the endodontic pathogen Enterococcus faecalis. Dr Tanujaa employs multi-omics and integrative omics platforms for translating basic research into clinical practice. Her work has been recognised with awards and publications in high impact internationally accredited journals.

Research Focus Areas

• Investigating the biofilm formation and drug resistance pathways of oral pathogens using multi and integrative omics approaches
• Endodontic microbiome analysis by 16s gene sequencing

Current Projects

• Identifying the biofilm formation and drug resistance pathways of Enterococcus faecalis using targeted metabolomics and integrative omics approaches
• Development of novel UV disinfection chamber for dental procedures

Publications and/or Research Projects

1. Ravichandran A, Ramachandran M*, Suriyanarayanan T*, Wong CC, Swarup S. Global regulator MorA affects virulence-associated protease secretion in Pseudomonas aeruginosa PAO1. PLoS ONE 2015;10(4):e0123805. doi:10.1371/journal.pone.0123805
2. Suriyanarayanan T, Periasamy S, Lin M-H, Ishihama Y, Swarup S. Flagellin FliC phosphorylation affects Type 2 protease secretion and biofilm dispersal in Pseudomonas aeruginosa PAO1. PLoS ONE. 2016;11(10):e0164155. doi:10.1371/journal.pone.0164155
3. Seneviratne CJ*, Suriyanarayanan T*, Swarup S, Chia KHB, Nagarajan N, Zhang C. Transcriptomics analysis reveals putative genes involved in biofilm formation and biofilm-associated drug resistance of Enterococcus faecalis. J Endod 2017;43(6):949-55.
4. Suriyanarayanan T, Qingsong L, Kwang LT, Mun LY, Truong T, Seneviratne CJ. Quantitative proteomics of strong and weak biofilm formers of Enterococcus faecalis reveals novel regulators of biofilm formation. Mol Cell Proteomics 2018;17(10):2081.
5. Truong T, Suriyanarayanan T, Zeng G, Le TD, Liu L, Li J, Cao T, Wang Y, Seneviratne CJ. Use of haploid model of Candida albicans to uncover mechanism of action of a novel antifungal agent. Front Cell Infect Microbiol 2018;8:164.

*Authors contributed equally

Book chapter

1. Suriyanarayanan T, Seneviratne CJ, Ng WL, Pavagadhi S, Swarup S. (2017) Metabolomics of Microbial Biofilms: Current Status and Future Directions in Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications, Ed Seneviratne CJ, CRC Press ISBN 9781498722193 - CAT#K25618.
2. Seneviratne CJ, Suriyanarayanan T, Qingsong L, Vizcaino JA. (2017) Proteomics Approaches to Uncover the Drug Resistance Mechanisms of Microbial Biofilms in Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications, Ed Seneviratne CJ, CRC Press ISBN 9781498722193 - CAT#K25618.