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Goh Bee Tin

Clinical Associate Professor Goh Bee Tin

  • Deputy Director, Research & Education, National Dental Centre Singapore
  • Director, Research, National Dental Centre Singapore
  • Director, National Dental Research Institute Singapore, National Dental Centre Singapore
  • Senior Consultant, Dept of Oral & Maxillofacial Surgery, National Dental Centre Singapore
  • Vice-Chair, Research, Oral Health Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre
  • Adjunct Associate Professor, Oral Health ACP, Duke-NUS Medical School
  • Clinical Associate Professor, Faculty of Dentistry, National University of Singapore
  • Adjunct Associate Professor, School of Chemical and Biomedical Engineering, Nanyang Technological University


A/Prof Goh obtained her Bachelor of Dental Surgery from the National University of Singapore in 1993. She then went on to specialise in Oral & Maxillofacial Surgery, obtaining her Dental Fellowship with the Edinburgh Royal College of Surgeons in 1996 and Master of Dental Surgery from NUS in 1997. In 2009, she obtained a PhD from Radboud University Nijmegen, the Netherlands for her novel research work on modular endoprosthesis for mandibular reconstruction.


Her expertise includes pre-clinical animal models and clinical trials. Highlights of her translational research work include the co-development and commercialisation of a bioresorbable polymer dental plug for ridge preservation, development of a modular endoprosthesis for mandibular reconstruction, of which patent has been filed in 6 different countries, and the development of a painless dental anaesthesia device using a combination of microneedle arrays and iontophoresis. She received the Osteopore Innovation Award for her work in clinical tissue engineering and the SingHealth GCEO Outstanding Clinician Researcher Award.



Research Focus Areas

  • Bone tissue engineering
  • Novel devices for mandibular reconstruction



Current Projects

  • A randomised clinical trial comparing the topical treatment of steroid and cyclosporine on oral lichen planus – Co-I
  • Bone healing and implant stability in a tooth extraction socket following the use of a bioresorbable three-dimensional polycaprolactone (PCL) scaffold for ridge preservation – PI
  • Modular endoprosthesis for mandibular reconstruction – Co-I
  • PCL-TCP scaffold for alveolar bone regeneration and immediate implant placement – PI
  • Modulation of migration and homing of neutrophils enhances osteogenesis and angiogenesis – PI
  • PCL-TCP scaffold with BMP-2 or heparan sulphate for bone regeneration during immediate dental implant placement in a micropig model – PI
  • The use of a biphasic calcium phosphate ceramic with bone morphogenetic protein-2 or heparan sulfate for bone regeneration during immediate dental implant placement in a micropig model – PI
  • 3D printed scaffold for ridge preservation after tooth extraction – a randomised controlled clinical trial – PI
  • From serendipity to predictability: A novel topographical-driven bioactive membrane for guided tissue regeneration – PI
  • Development of 3rd generation modular endoprosthesis for mandible reconstruction – PI
  • Conductive microneedle-mediated iontophoresis for non-invasive and painless local anesthesia in dentistry – PI
  • A novel technique using patient-specific polycaprolactone–tricalcium phosphate scaffold with adipose-derived mesenchymal stem cells for alveolar ridge augmentation – PI


Publications and/or Research Projects

  1. Goh BT, Teh LY. Odontoameloblastoma: Report of a case. Ann Acad Med Singapore 1999;28(5):749-52.

  2. Goh BT, Sim KM, Lestari MM. Outpatient third molar surgery under local anaesthesia and conscious sedation using patient – controlled analgesia with alfentanil. Singapore Dent J 2000;23(1 Suppl):23-8.

  3. Goh BT, Poon CY, Peck RH. The importance of routine magnetic resonance imaging in trigeminal neuralgia diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;92(4):424-9.

  4. Poon CY, Goh BT, Kim MJ et al. A randomized controlled trial to compare steroid and cyclosporine in the topical treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:47-55.

  5. Goh BT, Lee S, Tideman H, Stoelinga PJ. Mandibular reconstruction in adults: a review. Int J Oral Maxillofac Surg 2008 Jul;37(7):597-605.

  6. Lee S, Goh BT, Tideman H, Stoelinga PJ. Modular endoprosthesis for mandibular reconstruction: A preliminary animal study. Int J Oral Maxillofac Surg. 2008;37(10):935-42.

  7. Lee S, Goh BT, Tideman H, Stoelinga PJ, Jansen JA. Modular endoprosthesis for mandibular body reconstruction: a clinical, micro-CT and histologic evaluation in eight macaca fascicularis. Int J Oral Maxillofac Surg. 2009;38(1):40-7.

  8. Goh BT, Lee S, Tideman H, JA Jansen, Stoelinga PJW. Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis. Part 1: A clinical and radiographic study. J Oral Maxillofac Surg. 2009;67:1392-1400.

  9. Goh BT, Lee S, Tideman H, JA Jansen, Stoelinga PJW. Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis. Part 2: A microcomputed tomographic and histologic evaluation of the ramus and stem. J Oral Maxillofac Surg 2009;67:2617-26.

  10. Goh BT, Lee S, Tideman H, Stoelinga PJW, JA Jansen. Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis. Part 3: An evaluation of peri-implant bone remodelling. J Oral Maxillofac Surg 2010;68:1776-82.

  11. Goh BT, Lee S, Tideman H, JA Jansen, Stoelinga PJW. Replacement of the condyle and ascending ramus by a modular endoprosthesis in Macaca fascicularis. Part 4: Evaluation of the temporomandibular joints. J Oral Maxillofac Surg 2010;68(9):2136-45.

  12. Lee S, Goh BT, Lai SH, Tideman H, Stoelinga PJW, Jansen JA. Periimplant and systemic release of metallic elements following insertion of a mandibular modular endoprosthesis in Macaca fascicularis. Acta Biomater 2009;5(9):3640-6.

  13. Lee S, Goh BT, Wolke J, Tideman H, Stoelinga PJW, Jansen JA. Soft tissue adaptation to modified titanium surfaces. J Biomed Mater Res A 2010;95(2):543-9.

  14. BT Goh, S Lee, N Chanchareonsook, H Tideman. Modular endoprosthesis for mandibular reconstruction – A thematic research study at the National Dental Centre Singapore. Proceedings of Singapore Healthcare 2012;21(1):8-14.

  15. Goh BT, Chanchareonsook N, Tideman H, Teoh SH, Chow JK, Jansen JA. The use of a polycaprolactone-tricalcium phosphate scaffold for bone regeneration of tooth socket facial wall defects and simultaneous immediate dental implant placement in Macaca fascicularis. J Biomed Mater Res A 2014;102:1379-88.

  16. Goh BT, Teh LY, Tan DB, Zhang Z, Teoh SH. Novel 3D polycaprolactone scaffold for ridge preservation - a pilot randomised controlled clinical trial. Clin Oral Implants Res 2015;26(3):271-7.

  17. Goh BT, Teoh KH. Orbital implant placement using a computer-aided design and manufacturing (CAD-CAM) stereolithographic surgical template protocol. Int J Oral Maxillofac Surg 2015;44(5):642-8.

  18. Lim W, Lye KW, Goh BT. Osteochondroma of mandibular condyle: report of 2 surgical approaches.  Ann Maxillofac Surg 2014;4:215-9.

  19. Heng N,  Zahlten J, Cordes V,  Ong M, Goh BT, N'Guessan PD, Pischon N. The effects of enamel matrix derivative and transforming growth factor-ß1 on connective tissue growth factor in human periodontal ligament fibroblasts. J Periodontol 2015;86(4):569-77.

  20. Yam GH, Peh GS, Singhal S, Goh BT, Mehta JS. Dental stem cells: a future asset of ocular cell therapy. Expert Rev Mol Med 2015;17:e20.doi: 10.1017/erm.2015.16.

  21. Gao Y,  Lim J, Yeo DC, Liao S, Lans M, Wang Y, Teoh SH, Goh BT, Xu C. A selective and purification-free strategy for labeling adherent cells with inorganic nanoparticles. ACS Appl Mater Interfaces. 2016;8(10):6336-43. doi: 10.1021/acsami.5b12409.

  22. Schaller B, Saulacic, N, Beck S, Imwinkelried T, Goh BT, Nakahara K, Hofstetter W, Iizuka T. In vivo degradation of a new concept of magnesium-based rivet screws in the minipig mandibular bone. Mater Sci Eng Part C 2016;69:247-54.

  23. Sa Y, Yu N, Wolke JGC, Chanchareonsook N, Goh BT, Wang Y, Yang F, Jansen JA. Bone response to porous poly(methyl methacrylate) cement loaded with hydroxyapatite particles in a rabbit mandibular model. Tissue Eng Part C Methods. 2017;23(5):262-273. doi: 10.1089/ten.TEC.2016.0521.

  24. Hassanbhai AM, Lau CS, Wen F, Jayaraman P, Goh BT, Yu N, Teoh SH. In Vivo immune responses of cross-linked electrospun tilapia collagen membrane. Tissue Eng Part A 2017. doi: 10.1089/ten.tea.2016.0504. [Epub ahead of print]

  25. Xie Y, Su Y, Min S, Tang J, Goh BT, Saigo L, Ansari S, Moshaverinia A, Zhang C, Wang J, Liu Y, Khojasteh A, Zadeh HH, Wang S. Collagen sponge functionalized with chimeric anti-BMP-2 monoclonal antibody mediates repair of critical-size mandibular continuity defects in a nonhuman primate model. Biomed Res Int. 2017;2017:8094152. doi: 10.1155/2017/8094152.

  26. Herath TDK, Larbi A, Teoh SH, James Kirkpatrick C, Goh BT. Neutrophil-mediated enhancement of angiogenesis and osteogenesis in a novel triple cell co-culture model with endothelial cells and osteoblasts. J Tissue Eng Regen Med 2018;12(2):e1221-e1236.

  27. Guo L, Min S, Su Y, Tang J, Du J, Goh BT, Saigo L, Wang S, Ansari S, Moshaverinia A, Zadeh HH, Liu Y. Collagen sponge functionalized with chimeric anti-BMP-@ monoclonal antibody mediates repair of nonunion tibia defects in a nonhuman primate model: An exploratory study. J Biomater Appl 2017; 32(4):425-32.

  28. Yam GH, Teo EP, Setiawan M, Lovatt MJ, Yusoff NZBM, Fuest M, Goh BT, Mehta JS. Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy. J Cell Mol Med 2018;22(6):3119-32.

  29. Saigo L, Kumar V, Liu Y, Lim J, Teoh SH, Goh BT. A pilot study: Clinical efficacy of novel polycaprolactone-tricalcium phosphate membrane for guided bone regeneration in rabbit calvarial defect model. J Oral Maxillofac Surg Med Pathol 2018;30(3):212-9.

  30. Teoh SH, Goh BT, Lim J. Three-dimensional printed polycaprolactone scaffolds for regeneration success and future perspective. Tissue Eng Part A 2019;25(13-14):931-5.

  31. Lau CS, Hassanbhai A, Wen F, Wang D, Chanchareonsook, N, Goh BT, Yu N, Teoh SH. Evaluation of decellularized tilapia skin as a tissue engineering scaffold. J Tissue Eng Regen Med 2019;13(10):1779-91.