Cl Asst Prof Nattharee Chanchareonseok

• Researcher, NDRIS
• Senior Consultant, National Dental Centre Singapore
• Adjunct Assistant Professor, Duke-NUS Graduate Medical School

Dr Nattharee achieved her PhD for Medical Science from Radboud University Nijmegen, The Netherlands in 2014. As a clinician scientist at NDCS, she aims to pursue translational research and forge close links between the medical, scientific and medical device manufacturing communities. The research work she does will both advance dental research and facilitate translation of basic knowledge to the clinic.

She has received awards/patents as listed below:

1. NMRC Research Training Fellowship Award (MH 95:03/08-174) in 2010-2012
2. NMRC CNIG Grant (NMRC/CNIG15nov) in 2016-2018
3. Tan Kah Young Inventor's Award (TKKYIA) 2018
4. Mandible endoprosthesis implant, implant system, surgical kit, and methods for surgically repairing a mandible (Filed US Patent App. 16/084,501, pending approval)

Research focus areas

Dr Nattharee has a passion for medical technology and believes in the importance of translational research to help improve the quality of patients’ lives. Her extensive clinical experience allows her to understand the clinical problem and anticipate patient requirements right from the start of the research work. Her research experience has trained her to be proficient in experimental planning and she keeps abreast of tissue engineering advances in the field. Together, Dr Nattharee’s combined clinical and research skill-sets position her strategically in the design of research work from bench to bedside.

Dr Nattharee’s long term goal is to develop a new therapeutic approach that can facilitate bone regeneration, particularly for use in the oral and maxillofacial regions in patients. Currently, she works on a variety of different research projects and collaborates closely with researchers from the local institutions.

Current Projects

• Engineering bone grafts in a novel dynamic electromagnetic bioreactor

• Development of 3rd generation modular endoprosthesis for mandible reconstruction and a 2-step implantation approach for mandible reconstructio

• 3D printed scaffold device for ridge preservation after tooth extraction - A randomised controlled clinical trial
  

• A novel technique using patient-specific polycaprolactone–tricalcium phosphate scaffold with adipose-derived mesenchymal stem cells for alveolar ridge augmentation
  

• In vivo pulp revascularization by topotaxis-induced cell homing in Macaca fascicularis monkey teeth
  

• A biomaterials approach for endodontic (dental pulp) regeneration
  

• Nano-enabled Electrochemical Deposition (NEED) for anti-infective dental implants
  

• Establishing a CBCT scanning protocol for the fabrication of 3D models in autotransplantation
  

• Does bone plate surface topography directly influence soft tissue reaction? A comparison between sintered and milled titanium plates in an animal model

Publications and/or research projects

1)         Goh BT, Lee S, Chanchareonsook N, Tideman H. Modular endoprosthesis for mandibular reconstruction – A thematic research study at the National Dental Centre Singapore. Proceedings of Singapore Healthcare 2012;21(1):8-14.

3)         Chanchareonsook N, Tideman H, Feinberg SE, Hollister SJ, Jongpaiboonkit L, Kin L, Jansen JA. Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates: A rabbit study. J Biomed Mater Res Part A 2013:101A:2258-66.

4)         Goh BT, Chanchareonsook N, Tideman H, Teoh SH, Chow JK, Jansen JA. The use of a polycaprolactone-tricalcium phosphate scaffold for bone regeneration of tooth socket facial wall defects and simultaneous immediate dental implant placement in Macaca fascicularis. J Biomed Mater Res A. 2014;102(5):1379-88. doi: 10.1002/jbm.a.34817.

5)         Chanchareonsook N, Junker R, Jongpaiboonkit L, Jansen JA. Tissue-engineered mandibular bone reconstruction for continuity defects: a systematic approach to the literature. Tissue Eng Part B Rev. 2014;20(2):147-62. doi: 10.1089/ten.TEB.2013.0131.

6)         Chanchareonsook N, Tideman H, Feinberg SE, Jongpaiboonkit L, Lee S, Flanagan C, Krishnaswamy G, Jansen J. Segmental mandibular bone reconstruction with a carbonate-substituted hydroxyapatite-coated modular endoprosthetic poly(ɛ-caprolactone) scaffold in Macaca fascicularis. J Biomed Mater Res B Appl Biomater. 2014;102(5):962-76. doi: 10.1002/jbm.b.33077.

7)         Chanchareonsook N, Tideman H, Lee S, Hollister SJ, Flanagan C, Jansen JA. Mandibular reconstruction with a bioactive-coated cementless Ti6Al4V modular endoprosthesis in Macaca fascicularis. Int J Oral Maxillofac Surg 2014;43(6):758-68.

8)         Chanchareonsook N, Samman N, Whitehill TL. The effect of cranio-maxillofacial osteotomies and distraction osteogenesis on speech and velopharyngeal status: a critical review. Cleft Palate Craniofac J 2006;43(4):477-87.

9)         Chanchareonsook N, Whitehill TL, Samman N. Speech outcome and velopharyngeal function in cleft palate: comparison of Le Fort I maxillary osteotomy and distraction osteogenesis-early results. Cleft Palate Craniofac J 2007;44(1):23-32.

10)       Chaiyarit P, Utrawichian A, Leelayuwat C, Vatanasapt P, Chanchareonsook N, Samson MH, Giraud AS. Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma. Clin Oral Investig 2012;16(6):1549-56. doi: 10.1007/s00784-011-0667-z.