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Dr Chaminda Jayampath Seneviratne
Principal Investigator,
Academic Clinical Programme Office,
National Dental Centre Singapore

Dr Chaminda Jayampath's major research interests include oral microbiome in oral-systemic link, oral biofilm infections and salivary biomarkers. His research group employs OMICS biology techniques (microbiomics, proteomics and metabolomics) to unravel the molecular mechanisms underpinning the oral-systemic infections. He has developed various in vitro, ex vivo and in vivo biofilm models and small-molecule-based drug discovery platforms. Dr.Seneviratne’s research projects have been funded by NMRC-CS-IRG as well as industrial agents. He is a recipient of prestigious Awards from the International Association for Dental Research (IADR).


Education

  • Bachelor of Dental Surgery(BDS Hons),Department of Immunology(Pasture-Hong Kong University)
  • Master of Philosophy(MPhil),Department of Immunology(Pasture-Hong Kong University)
  • Doctor of Philosophy (PhD), Department of Immunology (Pasture-Hong Kong University)

  

Appointments

  • Clinical Scientist and Principal Investigator, National Dental Centre Singapore


Grants

  • NMRC CS-IRG, Evaluation of comparative in vitro and in vivo nephrotoxicity of novel antifungal agents


Selected Publications

  • Suriyanarayanan T, Qingsong L, Kwang LT, Mun LY, Seneviratne CJ. Quantitative Proteomics of Strong and Weak Biofilm Formers of Enterococcus faecalis Reveals Novel Regulators of Biofilm Formation.Mol Cell Proteomics. 2018 Apr;17(4):643-654. doi: 10.1074/mcp.RA117.000461. Epub 2018 Jan 22.PMID: 29358339
  • Pereira D, Seneviratne CJ, Koga-Ito CY, Samaranayake LP. Is the oral fungal pathogen Candida albicans a cariogen?Oral Dis. 2018 May;24(4):518-526. doi: 10.1111/odi.12691. Epub 2017 Jun 13. Review.PMID: 28513096
  • Dubey N, Ellepola K, Decroix FED, Morin JLP, Castro Neto AH, Seneviratne CJ, Rosa V. Graphene onto medical grade titanium: an atom-thick multimodal coating that promotes osteoblast maturation and inhibits biofilm formation from distinct species.Nanotoxicology. 2018 May;12(4):274-289. doi: 10.1080/17435390.2018.1434911. Epub 2018 Feb 6.PMID: 29409364
  • Truong T, Suriyanarayanan T, Zeng G, Le TD, Liu L, Li J, Tong C, Wang Y, Seneviratne CJ. Use of Haploid Model of Candida albicans to Uncover Mechanism of Action of a Novel Antifungal Agent.Front Cell Infect Microbiol. 2018 Jun 8;8:164. doi: 10.3389/fcimb.2018.00164. eCollection 2018.PMID: 29938200
  • Balan P, He HG, Cao F, Wong ML, Chong YS, Lopez V, Soh SE, Seneviratne CJ. Oral Health in Pregnant Chinese Women in Singapore: A Call to Go beyond the Traditional Clinical Care.Healthcare (Basel). 2018 Jul 9;6(3). pii: E77. doi: 10.3390/healthcare6030077.PMID: 29987265
  • Balan P, Chong YS, Umashankar S, Swarup S, Loke WM, Lopez V, He HG, Seneviratne CJ Keystone Species in Pregnancy Gingivitis: A snapshot of Oral Microbiome during pregnancy and Postpartum Period.Frontiers in Microbiology2018 Oct 9;9:2360. doi:10.3389/fmicb.2018.02360. eCollection 2018
  • Li P, Fung YE, Yin X, Seneviratne CJ, Che CM, Jin L. Controlled cellular redox, repressive hemin utilization and adaptive stress responses are crucial to metronidazole tolerance of Porphyromonas gingivalis persisters.J Clin Periodontol. 2018 Aug 20. doi: 10.1111/jcpe.13002. [Epub ahead of print]PMID: 30125959 • Balan P1, He HG2, Cao F3, Wong ML4, Chong YS5, Lopez V6, Soh SE7, Seneviratne CJ8. Oral Health in Pregnant Chinese Women in Singapore: A Call to Go beyond the Traditional Clinical Care. Healthcare (Basel). 2018 Jul 9;6(3). pii: E77. doi: 10.3390/healthcare6030077.
  • Hydrophobicity of graphene as a driving force for inhibiting biofilm formation of pathogenic bacteria and fungi.Dent Mater.
  • Nityasri Venkiteswaran, Lin Qinsong, Lim Teck Kwang, Cao Tong, Yue Wang, Chaminda Jayampath Seneviratne.Multi-omics unravel the comparative host response to haploid and diploid forms of Candida albicans to Journal of Investigative Dermatology