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Singapore Oro-Facial Initiative (SOFI)


SOFI is a tripartite collaboration among academic, clinical and industry partners to drive the development, translation and commercialisation of oro-facial innovations.

SOFI aims to:

  1. Develop oral devices and technologies with a focus on patient-specific implants and digital solutions, particularly for Asian oro-facial conditions and the elderly
  2. Drive oro-facial innovation, accelerate clinical translation and commercialisation by co-locating clinicians, surgeons, engineers and scientists within an integrated healthcare setting in Singapore
  3. Leverage the synergies of a multidisciplinary, multi-institutional and cross-industrial collaborative network to grow industry R&D investments


The oro-facial complex is an organ system comprising a complex network of muscular, skeletal, vascular, neuronal, sensory, respiratory and secretary tissues. Maintaining proper function or restoring function of the oro-facial complex is very important for quality of life, especially as a person ages.

With the rapidly ageing Singapore population, there is a growing need for innovative and cost-effective restorative, replacement and reconstructive solutions for the oro-facial complex, harnessing the latest advancements in the engineering arena, such as new imaging technologies, 3D printing and novel biomaterials.

Key Research Areas

​Patient-specific Devices ​Novel Bioactive Materials ​Integrated Digital Solutions
  • ​Dental implants
  • Dental prostheses
  • Oral appliances
  • Maxillofacial reconstruction/regeneration/cosmetic devices
  • ​Surface topographical modifications
  • Immunomodulation
  • Controlled-release therapeutics
  • ​3D/4D treatment and surgical planning algorithms for Asians
  • 3D printing

Core Research Platforms

SOFI has four core research platforms to support the key research areas:

  1. Advanced characterisation and manufacturing
  2. Digital technologies
  3. Clinical trials
  4. Business development

​Advanced Characterisation and Manufacturing
  • ​Rapid prototyping systems
  • Industrial scale micro-thermoforming, nano- and micro-patterning and electrospinning equipment
​Digital Technologies
  • ​2D and 3D clinical imaging
  • Clinical simulation for surgical and treatment planning
  • Computer-aided design, computer-aided manufacture and/or 3D printing
Clinical Trials
  • ​Investigator-initiated and industry-sponsored clinical trial support
  • GCP-trained clinical research coordinators
  • Administrative support
​Business Development
  • ​Industrial collaboration
  • Intellectual property protection
  • Licensing
  • Incubators
  • Commercialisation

Research & Impact

3D-Printed Dental Plug to Preserve Bone after a Tooth Extraction

3D printing for surgery planning

Modular endoprosthesis for mandible reconstruction


Cl A/Prof Goh Bee Tin