SOMI is an integrated research platform focusing on studies on the oral microbiome, oral biofilms and salivary biomarkers in clinical cohorts to effectively untangle the increasingly complex oral-systemic associations using advanced technologies such as genomics, proteomics and metabolomics.
SOMI aims to:
The oral microbiome is one of the most diverse and complex microbiomes in the human body. Dysbiosis of oral microbiome may have a potential effect on distant body sites as the microbiota disperse and gain access to the systemic circulation1. The oral microbiota has been shown to be associated with a number of systemic diseases, including cardiovascular disease, respiratory tract infections, gastrointestinal diseases and adverse gestational outcomes.
The SOMI research platform has been established to understand the pathobiology of oral infectious diseases and the link between oral microbiome and systemic diseases. SOMI aims to bridge the current knowledge gaps in our understanding of the oral-systemic link by multi-OMICS (genomics, proteomics and metabolomics) analysis of clinical samples pertaining to oral and systemic diseases. The high diversity of clinical cases at NDCS makes SOMI strategically well positioned to recruit the multitude of clinical cohorts required for these studies.
At SOMI, a multidisciplinary team of dental clinicians, dental clinician-scientists and platform experts works together to facilitate the identification of relevant clinical problems, investigation of the underlying pathogenesis mechanisms, development of innovative solutions and translation of these innovations into clinical practice.
1Han YW, Wang X. Mobile microbiome: oral bacteria in extra-oral infections and inflammation. Journal of Dental Research. 2013;92:485-91.
SOMI has three core research platforms to support our key research areas – technical, diagnostic and therapeutic. The applications of these platforms are summarised in the table below.
A/Prof Jaya Seneviratne (Lead)Cl A/Prof Marianne Ong Meng AnnCl A/Prof Mimi YowCl A/Prof Christina SimDr Lui Jeen NeeDr Chee Hoe KitDr Preethi PrajodDr Tanujaa SuriyanarayananDr Pang Li Mei
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5 Second Hospital Avenue, Singapore 168938 +65 6324 8802