Wisdom tooth Other area
Skip Ribbon Commands
Skip to main content

Singapore Oral Multiomics Initiative (SOMI)


SOMI is an integrated research platform focusing on studies exploring the oral microbiome, oral biofilms, genetics and salivary biomarkers to understand the burden of oral diseases and to untangle the increasingly complex oral-systemic associations.

SOMI aims to:

  1. Determine the causes of oral diseases and unravel the mechanisms behind the oral-systemic associations
  2. Explore the healthy and dysbiotic oral microbiome associated with oral and systemic diseases
  3. Develop novel therapeutics that modulate the oral and systemic conditions towards health
  4. Develop point-of-care diagnostics for oral and systemic diseases 



Oral chronic diseases result from an imbalanced inflammatory response to different local and systemic causes. The SOMI research platform has been established to understand the pathobiology of oral diseases and the link between oral and systemic conditions by utilizing multi-OMICS (genomics, proteomics and metabolomics) analysis and health-related and sociodemographic data. The high diversity of clinical cases at NDCS and SingHealth and the multitude of population-based cohorts in Singapore make SOMI strategically well-positioned to recruit the samples required for these studies.

At SOMI, a multidisciplinary team of dental clinicians, dental clinician-scientists and platform experts works together to facilitate the identification of relevant clinical problems, investigation of the underlying pathogenesis mechanisms, development of innovative solutions and translation of these innovations into clinical practice.


Key Research Areas

​Oral MicrobiomeOral Biofilms ​Salivary Biomarkers ​Genetics
  • ​Pathobiology of oral diseases
  • Link with systemic diseases
  • ​Anti-biofilm agents and devices
  • Microbiome-modulation therapy
  • Diagnostic and prognostic salivary biomarkers for oral and systemic diseases
  • ​Genetic and epigenetic modifications in oral diseases

Core Research Platforms

SOMI has three core research platforms to support our key research areas – technical, diagnostic and therapeutic. 

  • ​Metagenomics
  • Metaproteomics
  • Transcriptomics
  • Proteomics
  • Metabolomics
  • Epigenomics
  • ​Health vs disease-specific microbial signatures
  • In vitro, ex vivo screening models
  • Point-of-care devices
  • ​Microbiome and inflammation modulation therapy
  • Small-molecule based drug discovery
  • Anti-biofilm devices  

Research & Impact

The role of diabetes and cholesterol on oral inflammation

Antimicrobial agents for oral diseases

Oral microbiome and salivary biomarkers associated with gum disease in pregnancy and gestational diabetes mellitus


A/Prof Fabio Leite (Lead)

Cl A/Prof Mimi Yow

CI Asst Prof Lui Jeen Nee

Dr Chee Hoe Kit

Dr Preethi Prajod

Dr Tanujaa Suriyanarayanan

Dr Chelsia Sim

Dr Foo Lean Heong Lennie

Dr Wu Siwen