Projects

Modular Jaw Prostheses for Personalised Reconstruction

Over the past decade, the research team has developed several generations of modular mandibular endoprostheses—custom-designed implants that replace missing sections of the jaw. These implants are engineered to integrate directly with the patient's remaining jawbone through a natural process known as osseointegration, where bone grows onto the implant surface to create a strong and stable connection. Through a series of preclinical studies, researchers have continuously refined the design to improve stability, durability, and compatibility with surrounding tissues.

A key focus has been understanding the anatomy of the Asian mandible. Using advanced three-dimensional imaging, researchers have collected detailed measurements of jawbone dimensions in Singapore's population. This information enables the development of implants that provide a better anatomical fit, improving both function and appearance while supporting future large-scale manufacturing of standardized yet clinically relevant implant systems.

Patient-Specific Prostheses with Built-In Dental Rehabilitation

In parallel, the team is developing next-generation, patient-specific titanium jaw prostheses produced using advanced 3D-printing technologies. Unlike conventional reconstruction methods, these custom implants are designed to incorporate dental implants directly into the prosthetic system. This allows the implant to serve two important functions: (i) reconstructing the missing jawbone, (ii) supporting replacement teeth for functional rehabilitation. Because the dental implants integrate biologically with the remaining jawbone, they provide long-term stability while allowing patients to regain chewing function more effectively. This approach could simplify treatment, eliminate the need for bone grafting procedures, and facilitate earlier dental rehabilitation following cancer surgery or traumatic injury. Researchers are currently evaluating the mechanical performance, biological responses and long-term durability of these designs through in vitro tests and in vivo evaluations.

Biodegradable Scaffolds That Help the Jaw Regrow

Looking beyond permanent implants, NDRIS is also exploring regenerative approaches that encourage the body to rebuild its own jawbone. In collaboration with experts in advanced manufacturing and biofabrication, NDRIS researchers are developing patient-specific biodegradable scaffolds for the reconstruction of large jaw defects. These scaffolds are produced using sophisticated 3D-printing technologies and are designed to match each patient's anatomy precisely. The scaffolds combine biodegradable polymers and bone-like ceramic materials that gradually dissolve as new bone forms. Importantly, they are designed to mimic the natural structure of bone, providing an ideal environment for tissue regeneration.

The novel scaffolds can be further enhanced with the incorporation of piezoelectric biomaterials, which are materials capable of converting physical energy to electrical energy and vice versa. Natural bone generates tiny electrical signals when subjected to everyday forces such as chewing and movement. These signals play an important role in regulating bone growth and repair. Researchers are developing advanced scaffolds that can replicate this phenomenon. By converting normal jaw movements into microscopic electrical stimulation, the scaffold may continuously encourage new bone formation without requiring any external devices or treatments. This biomimetic approach has the potential to: (i) accelerate bone healing, (ii) improve blood vessel formation within the regenerated tissue, (iii) enhance the quality and organisation of newly formed bone, and (iv) reduce the need for additional procedures and long-term maintenance.