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Cyclophosphamide Injection

Drug Class: Commonly Known As: Category:
Immune Suppressant Cancer-related

Cyclophosphamide Injection - Dosage and How to Use

How should Cyclophosphamide Injection be used?

​Cyclophosphamide should be taken as prescribed by the doctor.. It can also be given by injection at the hospital every 1 to 2 week or every month.

Cyclophosphamide injection may be prescribed at a higher dose as compared to a typical oral adult dose which ranges from 50 milligrams to 150 milligrams to achieve faster control in more severe condition. Your doctor may reduce the dose if you have kidney or liver problem.

What should I do if I miss a dose?

If you forget your appointment and miss your injection, please make another appointment as soon as possible to arrange for next injection. Inform your doctor that you have missed your injection.

What should I do if I overdose?

Cyclophosphamide Injection - Additional Information

What are the special precautions while taking the medicine?

STOP taking Cyclophosphamide and let your doctor know if you develop an allergic reaction. Rash due to allergic reaction to Cyclophosphamide is rare. Possible symptoms of allergic reaction are:

  • rash, hives, or itching
  • red, swollen, blistered or peeling skin with or without fever
  • wheezing or tightness in the chest or throat
  • trouble breathing or talking
  • unusual hoarseness
  • swelling of the mouth, face, lips, tongue or throat

Cyclophosphamide may increase risk of developing certain kinds of infections due to reduced white blood cells (a key component of the body's immune system that helps to fight infections). Tell your doctor immediately if you experience any symptoms of infection such as temperature exceeding 38°C, chills, cough, painful or bloody urination, feeling very tired or weak.

Although rare, Cyclophosphamide may increase the risk of developing certain kinds of cancers, such as bladder cancer. The risk is higher with long term use and higher cumulative doses of Cyclophosphamide. Your doctor will perform periodic screening to manage the risk.

While having treatment with Cyclophosphamide, you must see your doctor as scheduled to monitor response to treatment and minimize any possible side effect.


Cyclophosphamide may cause infertility in both men and women. Although women taking Cyclophosphamide can stop having menses, some may experience early menopause, they can still become pregnant.

Both men and women of childbearing age must use a reliable method of contraception to avoid the risk of an unplanned pregnancy as Cyclophosphamide can cause serious defects to unborn child. You should not plan to have children while taking Cyclophosphamide or for a while after treatment.

Cyclophosphamide passes into human breast milk and may cause serious unwanted effects to the child. You should not breastfeed if you are taking Cyclophosphamide.

In SUMMARY… what you need to know about Cyclophosphamide?

Cyclophosphamide Injection is given at the hospital every 1-2 week or every month. A higher dose may be prescribed compared to the oral dose of 50 milligrams to 150 milligrams so as to achieve faster control in more sever condition.

 If you missed an appointment, schdule another appointment as soon as possible and inform your doctor that you have missed your injection.

Patient can experience side effects such as nausea and vomitting, hair loss, loss of appetite or weight, feeling tired or weakness, darkened skin colour and change in colour or growth of finger or toe nails. All these effects then to resolve spontaneously.


  • Updated on 3/15/2017 12:00:00 AM
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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