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Diazepam (Rectal)

Drug Class: Commonly Known As: Category:

Diazepam (Rectal) - What is it for

​Diazepam (rectal) is usually used in the emergency treatment of seizures (fits), including febrile (fever associated) seizures in children.

Most seizures are brief and stop spontaneously within 5 minutes. If a seizure does not stop by itself within 10 to 15 minutes, it is considered a medical emergency. Seizures lasting longer than 30 minutes may lead to brain and body injury.

Diazepam (Rectal) - Side Effects, Precautions, and Contraindications

What side effects can Diazepam (Rectal) cause?

The common side effects of rectal diazepam include:

  • Drowsiness
    • Avoid driving or engaging in activities (such as cycling or swimming) that requires concentration
  • Skin irritation or rash

If seizures persist despite use of rectal diazepam, seek medical attention immediately. 

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Diazepam (Rectal) , what precautions must I follow?

​Inform your healthcare professional if you have the following medical conditions before starting on diazepam (rectal):

  • Drug allergies
  • Acute narrow-angle glaucoma (an eye condition resulting from high pressure in the eye)
  • Myasthenia gravis (an immune condition affecting the nerves and muscles)
  • Liver problems
  • Kidney problems
  • Respiratory problems

What food or medicine must I avoid when I take Diazepam (Rectal) ?

​Use of diazepam (rectal) with opioids (a group of strong painkillers like morphine and fentanyl) may result in excessive drowsiness, breathing difficulties and in severe cases, coma or death.

Diazepam (Rectal) - Dosage and How to Use

How should Diazepam (Rectal) be used?

Use as directed by your doctor or follow the instructions in your seizure management plan.

Step 1: Tear open the foil pack.

Step 2: Twist and remove the cap from the nozzle of the diazepam (rectal) tube.


Step 3: Lay the patient on the stomach or side with a cushion under the hip.

Step 4: If the dose is half a tube, squirt out half of the tube's content.

Step 5: With the patient lying on his or her side, separate the buttocks.

Step 6: Insert the nozzle into the anus, but only to the first mark on the tube for children 1 to 3 years old.

Step 7: Always keep the tube angled with the nozzle downwards during administration.

Step 8: Squeeze the tube to empty the contents of the tube (by pressing with your thumb and index finger).

Step 9: Keep the tube pressed and remove the tube from the anus at the same time to prevent the medication from being sucked back into the tube.

Step 10: Hold the buttocks together for 3 to 4 minutes to prevent leakage.

What should I do if I miss a dose?

​Diazepam (rectal) is usually used on an as needed basis to stop a seizure episode.

What should I do if I overdose?

Diazepam (Rectal) - Handling

How should I handle Diazepam (Rectal) safely?

Diazepam (Rectal) - Storage

How should I store Diazepam (Rectal) ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

​It will be good to keep it near patients with epilepsy.

How should I dispose of Diazepam (Rectal) safely?

​Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin.

Diazepam (Rectal) - Additional Information

  • Updated on 8/31/2021 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth


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