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Cyproterone Acetate + Ethinylestradiol

Drug Class: Commonly Known As: Category:
Contraceptive Estelle-35/35 ED Adult

Cyproterone Acetate + Ethinylestradiol - Side Effects, Precautions, and Contraindications

What side effects can Cyproterone Acetate + Ethinylestradiol cause?

  • Spotting or bleeding may occur between your periods during the first 1-2 months of taking oral contraceptives. However, if this continues after the second month, check with your doctor
  • Nausea, vomiting, bloating and stomach cramps.
    • Take the medication after food to reduce these side effects.
  • Breast tenderness
  • Headache or migraine
    • You may take Paracetamol to manage headaches
  • Intolerance to contact lenses
  • Weight changes, mood swings.
    • Take medication at the same time every day to avoid huge changes in the hormone levels in your body.
  • Pigmentation (changes in colour) of the skin.
    • Apply sunblock when you are outdoors and avoid long hours of sun exposure.

Check with your doctor about any symptoms that becomes bothersome.

Using a combined hormonal medication increases a woman’s risk of developing blood clots compared with a woman not taking any combined hormonal medication. The risk of developing blood clots in a vein is highest during the first year a woman uses the medication. Other risk factors of developing blood clots include smoking and obesity. However, blood clot formation is rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.

  • The symptoms of blood clot include one or more of the following:
    • Any unusual sudden cough, breathlessness or difficulty in breathing
    • Severe pain in the chest which may reach the left arm
    • Severe pain in legs or swelling in either of your legs
    • Weakness or numbness in any part of your body
    • Change in your speech, including slurring of words
    • Change in your senses of hearing, smell or taste
    • Vision changes such as loss of vision/ blurred vision

Other rare but serious side effects that you may or may not experience.

  • Unusual, severe or long lasting headache or worsening of migraine
  • Dizziness or fainting
  • Severe pain in your abdomen
  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these side effects/ symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Cyproterone Acetate + Ethinylestradiol, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You have a history of or current medical conditions such as liver problems, stroke, heart disease, migraine headaches, epilepsy (fits), diabetes or cancer

If you are seeing other healthcare professionals for any other medical conditions, inform them that you are taking this medication.

What food or medicine must I avoid when I take Cyproterone Acetate + Ethinylestradiol?

Some medications including antibiotics and antifungals may affect how Estelle™-35/35ED works or be affected by Estelle™-35/35ED. Please inform other healthcare professionals about this medication you are taking if you are seeing them for other medical conditions.

Cyproterone Acetate + Ethinylestradiol - Additional Information

  • Updated on Monday, September 30, 2019
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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