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Hormone Replacement Therapy

Drug Class: Commonly Known As: Category:
Hormone Premarin®, Estrofem®, Progynova®, Activelle®, Femoston®, Trisequens®, Progyluton® Adult

Hormone Replacement Therapy - Dosage and How to Use

How should Hormone Replacement Therapy be used?

  • Do not stop taking your medication without checking with your healthcare professional.
  • You should take this medication after food.

The regimen depends on the HRT that you have been prescribed. Some brands have different coloured tablets to take on certain days.

The following are some commonly used HRT regimens: 

  • Estrogen only HRT e.g. Premarin® / Estrofem® / Progynova®
    • You should take one tablet daily without break, preferably at the same time every day.
    • If you have an intact uterus and are still menstruating, your doctor would prescribe a separate progestogen hormone as well to take for a specific duration (usually 10 – 14 days) each month. In this case, you will experience a withdrawal bleed after finishing the progestogen tablets.
  • Continuous combined therapy e.g. Activelle®, Femoston® Conti 1/5
    • You should take one tablet daily without break, preferably at the same time every day.
  • Continuous Estrogen and Cyclic Progestogen Therapy e.g. Femoston® 1/10 and Femoston® 2/10
    • Usually contains 14 tablets containing estrogen only, and 14 tablets containing estrogen and progestogen, in one pack.
    • You should take one tablet daily without break, preferably at the same time every day.
    • When a pack is finished, the next pack should be started without any break.
    • You will experience a withdrawal bleed once a month after completion of each pack.
  • Triphasic therapy e.g. Trisequens®
    • Contains estrogen tablets and combined estrogen and progestogen tablets in varying doses, in one pack.
    • You should take one tablet daily without break, preferably at the same time every day.
    • When a pack is finished, the next pack should be started without any break.
    • You will experience a withdrawal bleed once a month.
  • Cyclic Estrogen and Progestogen e.g. Progyluton®
    • Contains estrogen tablets and combined estrogen and progestogen tablets, in one pack.
    • You should take one tablet daily for 21 consecutive days, preferably at the same time every day. Then, stop for 7 days – during which time a withdrawal bleed usually occurs.
    • Subsequent pack is to be started after the 7 tablet-free days are over, even if you still have bleeding

What should I do if I miss a dose?

  • Take the missed dose as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.
  • You may have vaginal bleeding or spotting if you forget to take more than 1 tablet. Please ask your doctor for advice.

What should I do if I overdose?

Hormone Replacement Therapy - Additional Information

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