Wisdom tooth Other area
Skip Ribbon Commands
Skip to main content


Drug Class: Commonly Known As: Category:
Nicotine Nicotinell® Adult

Nicotine - Side Effects, Precautions, and Contraindications

What side effects can Nicotine cause?

  • Throat irritation
  • Jaw ache
  • Increased salivation
  • Hiccups
  • Dry mouth
  • Flatulence
  • Stomach discomfort
  • Heartburn
  • Nausea and vomiting
  • Dizziness
  • Headache

These side effects usually occur as a result of intense sucking of lozenges. Suck the lozenge slowly and take longer breaks in between lozenges to reduce these side effects.

The symptoms of a drug allergy include one or more of the following: 

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Nicotine , what precautions must I follow?

​You should stop smoking once you start to use NRT. Smoking and using NRT at the same time may increase the risk of adverse effects from the additive effects of nicotine in your body.
If you continue to feel the urge to smoke or experience severe nicotine withdrawal symptoms even after using the NRT lozenges, please inform your healthcare professional as you may need other types of NRT.
Inform your healthcare professional if:

  • You are pregnant, planning to become pregnant, or breastfeeding.
  • You recently had a heart attack or stroke.
  • You have active peptic ulcer disease.
  • You have any other medical conditions.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies.
  • You are less than 18 years old.

What food or medicine must I avoid when I take Nicotine ?

  • ​Avoid coffee, tea, juices, acidic and fizzy drinks 15 minutes before and during use of nicotine lozenge as this may reduce nicotine absorption.
  • Nicotine may reduce the effect of certain medications. When NRT dose is reduced or stopped, adjustments to these medications may be necessary.
  • These medications include:
    • Benzodiazepines (e.g. diazepam, lorazepam)
    • Insulin
    • Beta-blocker (e.g. bisoprolol, atenolol)
    • Opioid painkillers (e.g. codeine)
  • Inform your doctor or pharmacist about other medications – including over-the-counter medications, supplements and traditional/herbal remedies – that you are currently taking as they may affect the way you benefit from NRT.

Nicotine - Additional Information

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

​If you take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare professional for more information.

Find Your Medicines