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Prochlorperazine - Side Effects, Precautions, and Contraindications

What side effects can Prochlorperazine cause?

  • ​Constipation
    • Drink more water (if not fluid restricted), eat more high fibre foods
  • Dry mouth
  • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
    • Dry eyes 
  • Use a lubricating eye drop
    • Light-headedness (especially during a sudden change in posture)
    • Get up slowly from sitting or lying down position
      • Feeling tired or drowsy 
    • Avoid driving or engaging in activities requiring concentration 

    Before taking Prochlorperazine , what precautions must I follow?

    ​Inform your healthcare professional if: 

    • You are allergic to this medication or any of the other ingredients of this medication
    • You are pregnant, planning to become pregnant, or breastfeeding
    • You are taking any other medications, including supplements, traditional medications and herbal remedies
    • Medical conditions such as heart disease, dementia, liver and kidney disease, seizure (fits), phaeochromocytoma (tumour on the adrenal gland)

    What food or medicine must I avoid when I take Prochlorperazine ?

    ​Avoid drinking alcohol while taking this medication as it can increase drowsiness side effect 

    Prochlorperazine - Additional Information

    ​The symptoms of a drug allergy include one or more of the following: 

    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

    Rarely this medication may cause:

    •  High fever, severe muscle stiffness, confusion, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome)
    • Muscle stiffness and spasms (such as in the face, neck and back), difficulty in speaking or swallowing, twitching or upward rolling of eyes (dystonia)
    • Uncontrollable movements (such as in the face, tongue, jaw or other parts of the body) ({tardive dyskinesia)
    • Fever, sore throat and/or mouth ulcers that do not go away (symptoms of blood dyscrasia)
    • Increased prolactin hormone in the blood (hyperprolactinemia)
      • Changes in menstrual cycle in females (irregular or stopping of menstrual periods) and/or
      • Abnormal breast swelling, soreness or secretion (in both men and women)  

    If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately

    • Updated on 7/31/2022 12:00:00 AM
    • Article contributed by Sengkang General Hospital Sengkang General Hospital
    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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